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C. Difficile Vaccine Study Spreadsheet


 Qualified participants must be age 50 years or older who:

  • have received an antibiotic in the last 12 months
  • have had at least 2 hospital stays in the last 12 months (each hospital admission must have included an overnight stay)


  • anticipating an in-patient hospitalization that will require a stay of 72 hours minimum

What is C. difficile??

C. difficile, also known as C. diff and Clostridium difficile, is an intestinal bacteria and one of the most important cause of infectious diarrhea in the U.S. It is most likely to affect patients in hospitals or long-term care facilities. Symptoms of mild cases include watery diarrhea, three or more times a day for several days, accompanied by abdominal pain or tenderness.Other risk factors for C. diff infection include:

  • Surgery of the gastrointestinal (GI) tract
  • Diseases of the colon such as inflammatory bowel disease or colorectal cancer
  • A weakened immune system
  • Use of chemotherapy drugs
  • Previous C. diff infection
  • Advanced age — 65 or older
  • Kidney disease
  • Use of drugs called proton-pump inhibitors, which reduce stomach acid
CategoryClinical Studies
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